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Related Experiment Video

Updated: Feb 11, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

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Hydrolyzed Formula Compared With Standard Formula for Preterm Infants.

Derek H C Ng¹, Nicholas D Embleton², William McGuire¹

¹Centre for Reviews and Dissemination, University of York, York, England.

|May 1, 2018

Summary

This summary is machine-generated.

Hydrolyzed formula does not improve outcomes for preterm infants. This specialized infant formula was not linked to reduced feeding intolerance, necrotizing enterocolitis, or enhanced growth compared to standard cow

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Area of Science:

Neonatal nutrition
Gastroenterology
Pediatric clinical trials

Background:

Preterm infants are at high risk for feeding issues and gastrointestinal complications.
Standard cow's milk formula is commonly used, but concerns exist regarding tolerance and specific morbidities.

Purpose of the Study:

To evaluate if hydrolyzed formula reduces feeding intolerance in preterm infants.
To determine if hydrolyzed formula lowers the incidence of necrotizing enterocolitis.
To assess the impact of hydrolyzed formula on growth rates in preterm infants.

Main Methods:

A comparative study design was employed.
Preterm infants were fed either hydrolyzed formula or standard cow's milk formula.
Outcomes measured included feeding intolerance, necrotizing enterocolitis rates, and growth parameters.

Main Results:

Hydrolyzed formula was not associated with a lower rate of feeding intolerance compared to standard formula.
No significant difference was observed in the rates of necrotizing enterocolitis between the two feeding groups.
Growth rates were comparable between preterm infants receiving hydrolyzed formula and those on standard formula.

Conclusions:

Hydrolyzed formula does not offer advantages over standard cow's milk formula for preterm infants regarding feeding tolerance, necrotizing enterocolitis, or growth.
Current evidence does not support the routine use of hydrolyzed formula for improving key outcomes in this population.