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Updated: Feb 11, 2026

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
Published on: April 17, 2012
Osteoblast response to Vitamin D3 loaded cellulose enriched hydroxyapatite Mesoporous silica nanoparticles composite
Murugan Sumathra1, Murugan A Munusamy2, Abdulla A Alarfaj2
1Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India.
Abstract:
Composite materials hold cellulose(C) established network and biomimetic Hydroxyapatite (HAP) are potentially appropriate for bone formation and protect the external organisms. Tissue engineering scaffolds with unified porous and enhanced biological properties can be fabricated using a small quantity of porous additives. In this study we synthesizd a Cholecalciferol (VD3) loaded, cellulose functionalized hydroxyapatite nanocomposites with different concentration of Mesoporous silica nanoparticles (MSNs). VD3 plays an important role in the bone formation by regulating extracellular levels of calcium and phosphorus. FTIR, SEM, TEM, and X-ray diffraction techniques were used for the characterization of the prepared composites. VD3 releases from the VD3/C/HAP/MSN scaffold were observed by using UV-vis spectroscopy. The nanocomposites C/HAP/MSN, VD3/C/HAP/MSN showed higher viability compared with pure HAP and in-vitro studies revealed that the materials has enhanced the proliferative, adhesion, osteoinductive effects ALP activity and calcium deposition assay on osteoblasts like cells (MG63). Our outcome recommended that the 3D like VD3 loaded C/HAP/MSN nanocomposite scaffolds have a great potential as a bone tissue substitute.
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