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Updated: Feb 11, 2026
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
Molecular Landscape in Alveolar Soft Part Sarcoma: Implications for Molecular Targeted Therapy
Mohammad Hasan Soheilifar1, Ramezan Ali Taheri2, Reza Zolfaghari Emameh3
1Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Research Center for Molecular Medicine and Genetics, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.
Abstract:
Alveolar soft part sarcoma (ASPS) is a highly aggressive rare soft tissue sarcoma (STS) with poor prognosis especially in the metastatic form. ASPS is resistant to standard chemotherapy. Although, early diagnosis and surgical resection of operable tumor could lead to improved patient survival but novel treatment options are needed for advanced (metastatic) ASPS. This malignancy exhibits highly angiogenic behavior which reflects hyper-activation and over expression of angiogenic factors. Understanding the molecular events in this type of sarcoma is important in finding novel molecular based targeted therapies. We aim to review molecular aspects of ASPS growth and treatment.
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