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3,5'-Anhydrosynadenol: A Polycyclic Anhydronucleoside Analogue
1Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 E. Warren Ave., Detroit, MI 48201-1379 (USA), Fax: (+1) 313-832-7294.
Angewandte Chemie (International Ed. in English)
|May 2, 2018
Abstract:
Cyclization instead of O-phosphorylation is the result of the reaction of the antiviral nucleoside anologue 1 with highly reactive phosphorylating agents. The formation of the novel polycyclic compound 2 shows that 1 has the Z configuration, which is important for the antiviral activity of 1 and related compounds.