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In vitro Assembly of Semi-artificial Molecular Machine and its Use for Detection of DNA Damage
Published on: January 11, 2012
An Artificial Regulatory System with Coupled Molecular Switches
Herbert Plenio1, Clemens Aberle1
1Institut für Anorganische und Analytische Chemie der Universität, Albertstrasse 21, D-79104 Freiburg (Germany), Fax: (+49) 761-203-5987.
Abstract:
The availability of sodium ions can be regulated indirectly (through electron transfer reactions) and reversibly through the addition and removal of zinc ions. In this cyclic process (depicted on the right) a redox-responsive ferrocene substituted with two dipicolylamino ligands (Fcdpa) coordinates two Zn2+ ions, while a redox-switchable ferrocene cryptand (Fccrypt) only forms stable complexes with Na+ when the ligand is in its reduced form. L is a strong ligand such as 1,4,8,11-tetraazacyclotetradecane.
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