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Asymmetric Synthesis of Bryostatin 2
David A Evans1, Percy H Carter1, Erick M Carreira1
1Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138 (USA), Fax: (+1) 617-495-1460.
Abstract:
The potent bryostatin antitumor agents are currently in phase II clinical trials for the treatment of a variety of forms of cancer. Aldol reactions and directed reductions are among the essential steps for the formation of fragments A-C in the total synthesis of the title compound. Coupling of these fragments by sulfone-based olefination and alkylation reactions was followed by macrocyclization and introduction of the enoate moieties on rings B and C.
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