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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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Updated: Feb 11, 2026

Nanomanipulation of Single RNA Molecules by Optical Tweezers
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RNA and the Small Molecule World.

Yitzhak Tor1

  • 1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358 (USA), Fax: (+1) 619-534-5383.

Angewandte Chemie (International Ed. in English)
|May 2, 2018
PubMed
Summary

Small molecules like tobramycin can regulate gene expression by interacting with messenger RNA (mRNA). This discovery highlights RNA

Area of Science:

  • Molecular Biology
  • Drug Discovery
  • Biochemistry

Background:

  • RNA molecules are crucial for cellular processes.
  • RNA's complex 3D structures create binding sites.
  • RNA structural motifs are targets for therapeutic intervention.

Purpose of the Study:

  • To explore the potential of small molecules in modulating RNA function.
  • To investigate the interaction between small molecules and messenger RNA (mRNA).
  • To demonstrate RNA-targeted gene regulation by small molecules.

Main Methods:

  • Utilizing small molecule screening.
  • Investigating specific molecular interactions.
  • Assessing gene expression regulation in cellular models.
Keywords:
AminoglycosidesAntibioticsGene technologyRNATranslation

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Main Results:

  • Small molecules, exemplified by tobramycin, can bind to specific mRNA structures.
  • These interactions lead to the regulation of gene expression.
  • Demonstrated a novel mechanism for controlling cellular processes via mRNA targeting.

Conclusions:

  • Messenger RNA (mRNA) is a viable target for small molecule drugs.
  • Specific small molecules can precisely regulate gene expression.
  • This work opens new avenues for RNA-targeted therapeutics.