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Updated: Feb 11, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Synthesis and Characterization of a Unimolecular Capsule
Marcus S Brody1, Christoph A Schalley1, Dmitry M Rudkevich1
1The Skaggs Institute for Chemical Biology and, Department of Chemistry, The Scripps Research Institute, MB-26, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 619-784-2876.
Abstract:
There is more than one way to assemble the two halves of a tethered, urea-substituted calix[4]arene dimer (shown schematically): formation of unimolecular capsules (far left), dimers, or oligomers. By combination of NMR spectroscopy and electrospray mass spectrometry, a hexamethylene spacer was shown to be exactly right to permit the preferential formation of a unimolecular capsule under inclusion of solvent or other guest molecules.
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