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A Short Synthesis of (±)-Matrine
Laurent Boiteau1, Jean Boivin1, Annie Liard2
1Laboratoire de Synthèse Organique associé au CNRS, Ecole Polytechnique, 91128 Palaiseau Cedex (France), Fax: (+33) 1 69-33-30-10.
Abstract:
Three different radical reactions were used in a short total synthesis of (±)-matrine (1). Two of the four six-membered rings and four new bonds were created in one radical cascade involving intermolecular addition followed by two successive cyclizations and transfer of a xanthate group.
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