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Updated: Feb 11, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
Published on: November 1, 2019
PNA: Synthetic Polyamide Nucleic Acids with Unusual Binding Properties
Eugen Uhlmann1, Anusch Peyman1, Gerhard Breipohl1
1Hoechst Marion Roussel Deutschland GmbH, G 838, D-65926 Frankfurt am Main (Germany), Fax: (+49) 69-305-89713.
Abstract:
The astonishing discovery that peptide nucleic acids (PNAs, B=nucleobase), in spite of their drastic structural difference to natural DNA, are better nucleic acid mimetics than many other oligonucleotides has resulted in an explosion of research into this class of compounds. The synthesis, physical properties, and biological interactions of PNAs as well as their chimeras with DNA and RNA are summarized here.
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