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Updated: Feb 11, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
A New Strategy for the Destabilization of Double-Stranded Nucleic Acids by Phenylalkylamine Derivatives
Anmar Ali1, Martin Gasiorek1, Hans-Jörg Schneider1
1FR 11.2 Organische Chemie der Universität des Saarlandes, D-66041 Saarbrücken, Fax: (+49) 691-302-4105.
Abstract:
Drastic reduction in the melting points indicates considerable destabilization of double-stranded (ds) nucleic acids by stabilization of unfolded polymer parts with phenylalkylamine derivatives. These ligands cannot intercalate into ds duplex forms, but can stack with unfolded parts if the spacers separating the phenyl rings have the appropriate length.
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