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Properties of Transition Metals02:58

Properties of Transition Metals

30.0K
Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
30.0K
Coupled Reactions01:17

Coupled Reactions

10.8K
Cellular processes such as building and breaking down complex molecules occur through stepwise chemical reactions. Some of these chemical reactions are spontaneous and release energy, whereas others require energy to proceed. Cells often couple the energy-releasing reaction with the energy-requiring one to carry out important cell functions. 
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions....
10.8K
SN2 Reaction: Transition State02:26

SN2 Reaction: Transition State

12.0K
An SN2 reaction of an alkyl halide is a single-step process in which bond formation between the nucleophile and the substrate and bond breaking between the substrate and the halide occurs simultaneously through a transition state without forming an intermediate.
When the nucleophile approaches the electrophilic carbon with its lone pairs, the halide acts as a leaving group and moves away with the electron-pair bonded to the carbon. Dotted partial bonds represent the bonds being formed or broken...
12.0K
Base-Catalyzed Aldol Addition Reaction01:08

Base-Catalyzed Aldol Addition Reaction

4.6K
As depicted in Figure 1, base-catalyzed aldol addition involves adding two carbonyl compounds in aqueous sodium hydroxide to form a β-hydroxy carbonyl compound.
4.6K
Acid-Catalyzed Aldol Addition Reaction01:15

Acid-Catalyzed Aldol Addition Reaction

3.3K
The aldol reaction of a ketone under acidic conditions successfully forms an unsaturated carbonyl as the final product instead of an aldol. The acid-catalyzed aldol reaction is depicted in Figure 1.
3.3K
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

24.4K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
24.4K

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Related Experiment Video

Updated: Feb 11, 2026

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

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Transition Metal Catalyzed Coupling Reactions under C-H Activation.

Gerald Dyker1

  • 1Fachbereich 6 Institut für Synthesechemie der Universität-Gesamthochschule, Lotharstrasse 1, D-47048 Duisburg (Germany), Fax: (+49) 0203-379-4192.

Angewandte Chemie (International Ed. in English)
|May 2, 2018
PubMed
Summary

Transition metal catalysts enable C-C coupling via C-H activation, creating diverse products. A specific reaction demonstrates C-H activation of a methyl group in ortho-iodoanisole to form multiple C-C bonds.

Keywords:
C−C couplingC−H activationHomogeneous catalysisTransition metals

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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
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Area of Science:

  • Organic Chemistry
  • Catalysis

Background:

  • C-C coupling reactions are fundamental in organic synthesis.
  • Transition metal catalysis of C-H activation offers efficient synthetic routes.
  • Diverse applications exist, from basic chemicals to pharmaceuticals.

Purpose of the Study:

  • To explore C-C bond formation via C-H activation.
  • To investigate the conversion of ortho-iodoanisole.

Main Methods:

  • Utilizing transition metal catalysts.
  • Employing C-H activation strategies.
  • Focusing on methyl group activation.

Main Results:

  • Demonstrated C-C coupling under C-H activation conditions.
  • Achieved the formation of multiple C-C bonds.
  • Successfully converted ortho-iodoanisole.

Conclusions:

  • C-H activation is a powerful tool for C-C bond formation.
  • The conversion of ortho-iodoanisole represents a key example of this methodology.