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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
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A Method for High-Throughput Screening of Enantioselective Catalysts
Manfred T Reetz1, Michael H Becker1, Heinz-Werner Klein1
1Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr (Germany), Fax: (+49) 208-306-2985.
Angewandte Chemie (International Ed. in English)
|May 2, 2018
Summary
This study introduces a rapid method for analyzing asymmetric reactions using electrospray ionization mass spectrometry. It enables high-throughput determination of enantioselectivity for diverse chemical transformations.
Area of Science:
- * Organic Chemistry
- * Analytical Chemistry
- * Mass Spectrometry
Background:
- * Asymmetric synthesis is crucial for producing enantiomerically pure compounds.
- * High-throughput screening methods are needed to accelerate catalyst discovery and reaction optimization.
- * Traditional methods for determining enantioselectivity can be time-consuming and labor-intensive.
Purpose of the Study:
- * To develop a highly efficient method for analyzing asymmetric reactions.
- * To enable rapid determination of enantioselectivity using mass spectrometry.
- * To facilitate high-throughput screening of catalytic and stoichiometric asymmetric reactions.
Main Methods:
- * Development of a method analyzing up to 1000 reactions per day.
- * Utilization of electrospray ionization mass spectrometry (ESI-MS) for analysis.
- * Employing isotopically labeled substrates to differentiate enantiomers or pseudo-enantiomers.
Main Results:
- * Demonstrated high efficiency with analysis of approximately 1000 reactions daily.
- * Successfully determined enantioselectivity by analyzing mass spectra of reaction mixtures.
- * Validated the method using hydrolysis of a model compound yielding pseudo-enantiomeric products.
Conclusions:
- * The developed ESI-MS method offers a significant advancement in analyzing asymmetric reactions.
- * This approach allows for rapid and efficient high-throughput screening in asymmetric synthesis.
- * The method is applicable to a wide range of racemic compounds and prochiral substrates.
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