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Updated: Feb 11, 2026

Neural Tube Closure in Mouse Whole Embryo Culture
Published on: October 21, 2011
Closure of the Cavity in Permethylated Cyclodextrins through Glucose Inversion, Flipping, and Kinking
Thomas Steiner1, Wolfram Saenger1
1Institut für Kristallographie der Freien Universität, Takustrasse 6, D-14195 Berlin (Germany), Fax: (+49) 30-838-6702.
Abstract:
Glucose-flips in a small cycloamylose: the molecular structure of permethylated γ-cyclodextrin, which crystallizes as the dihydrate, is characterized by 180° flips of two diametrically opposed glucose residues. This leads to an elliptical distortion of the molecule and closure of the molecular cavity on one side so that it is no longer doughnut-shaped but is bowl-shaped. The hydrate water molecules are not located in the cavities!
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