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Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
Published on: November 29, 2019
Concise and Efficient Total Syntheses of Alkannin and Shikonin
K C Nicolaou1, David Hepworth1
1Department of Chemistry (and) The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 619-784-2469 (and) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA).
Abstract:
Two enantiomic natural products with wound-healing properties, alkannin (1) and shikonin (2), are accessible by a short and efficient total synthesis. The success was achieved by a novel protecting system for masking of 5,8-dihydroxy-1,4-naphthoquinones (naphthazarins) and a highly stereoselective ketone reduction.
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