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Updated: Feb 11, 2026

Identifying Protein-protein Interaction Sites Using Peptide Arrays
Published on: November 18, 2014
Protein Mimicry: A New Dimension for Peptides as Lead Compounds?
Ulrich Reineke1, Jens Schneider-Mergener1
1Institut für Medizinische Immunologie, Universitätsklinikum Charité, Humboldt-Universität, Schumannstrasse 20/21, D-10098 Berlin (Germany), Fax: (+49) 30-2802-6460.
Abstract:
A short peptide as mimic for the hemopoietic growth factor erythropoietin (containing 165 amino acids) could be identified with the aid of peptide libraries on phage surfaces (phage display). The crystal structure of a peptide dimer complexed with two erythropoietin receptors (shown on the right) provides an insight into the molecular basis of this protein mimicry.
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