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Solid-Phase Synthesis and Encoding Strategies for Olefin Polymerization Catalyst Libraries.

Thomas R Boussie1, Carla Coutard1, Howard Turner1

  • 1Symyx Technologies, 3100 Central Expressway, Santa Clara, CA 95051 (USA), Fax: (+1) 408-748-0175.

Angewandte Chemie (International Ed. in English)
|May 2, 2018
PubMed
Summary
This summary is machine-generated.

Novel resin-bound diimine complexes of nickel(II) and palladium(II) were synthesized for active polymerization catalysis. Fluorescent tagging and HPLC analysis enable tracking of reaction pathways for these coded catalysts.

Keywords:
Combinatorial chemistryHeterogeneous catalysisPolymersSolid-phase synthesis

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Area of Science:

  • Polymer Chemistry
  • Catalysis
  • Organic Synthesis

Background:

  • Development of efficient polymerization catalysts is crucial for materials science.
  • Resin-bound catalysts offer advantages in separation and recycling.
  • Diimine complexes of nickel and palladium are known for catalytic activity.

Purpose of the Study:

  • To synthesize novel resin-bound diimine complexes of nickel(II) and palladium(II).
  • To create a coded catalyst library for tracking reaction pathways.
  • To enable product pathway determination using High-Performance Liquid Chromatography (HPLC).

Main Methods:

  • Combinatorial synthesis of nickel(II) and palladium(II) diimine complexes.
  • Immobilization of catalysts onto a polymer-coated resin.
  • Tagging of catalysts with fluorescent markers.
  • Cleavage of fluorescent tags post-reaction.
  • Analysis of reaction pathways using HPLC.

Main Results:

  • Successful synthesis of novel resin-bound diimine complexes.
  • Development of a fluorescent tagging system for catalyst coding.
  • Demonstration of HPLC's utility in determining reaction pathways for coded catalysts.
  • Creation of a catalyst library for polymerization studies.

Conclusions:

  • Resin-bound diimine complexes of nickel(II) and palladium(II) are effective active polymerization catalysts.
  • Fluorescent tagging provides a method for coding catalysts.
  • HPLC analysis of cleaved tags allows for the elucidation of reaction pathways.
  • This approach facilitates the study of complex catalytic systems.