Resolution of Racemates: Did You Say "Classical"?

A successful "family approach" is already being used in industry for large-scale enantiomeric resolutions. In this method, racemates are resolved by formation of salts with mixtures of three structurally related resolving agents instead of a single one. Although the physical chemistry behind this is still largely unexplored, successful resolution is more likely and resolution efficiency is often improved over that of classical resolution.