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Total Synthesis of Chatancin
Josef Aigner1, Edda Gössinger1, Hanspeter Kählig1
1Institut für Organische Chemie der Universität, Währingerstrasse 38, A-1090 Wien (Austria), Fax: (+43) 131-367-2280.
Angewandte Chemie (International Ed. in English)
|May 2, 2018
Summary
Researchers synthesized chatancin, a potential therapeutic compound from soft coral, in racemic form. This study also achieved formal total syntheses of both natural and unnatural enantiomers of chatancin.
Area of Science:
- Marine natural products chemistry
- Organic synthesis
- Medicinal chemistry
Background:
- Chatancin is a diterpene isolated from soft coral.
- Chatancin acts as an antagonist of platelet-activating factor.
- Platelet-activating factor antagonists have potential therapeutic applications.
Purpose of the Study:
- To describe the first total synthesis of racemic chatancin.
- To achieve formal total syntheses of natural (+)-chatancin and unnatural (-)-chatancin.
Main Methods:
- Total synthesis of chatancin.
- Formal total synthesis of enantiomers.
Main Results:
- The first total synthesis of racemic chatancin was accomplished.
- Formal total syntheses of both (+)-chatancin and (-)-chatancin were achieved.
Conclusions:
- The synthetic accessibility of chatancin and its enantiomers is established.
- This work provides a foundation for further investigation of chatancin's therapeutic potential.
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