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Updated: Feb 11, 2026

Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry
Published on: March 18, 2012
Flavin- and Deazaflavin-Containing Model Compounds Mimic the Energy Transfer Step in Type-II DNA-Photolyases
1Laboratorium für Organische Chemie, ETH-Zentrum, Universitätstrasse 16, CH-8092 Zürich (Switzerland), Fax: (+41) 1-632-1109.
Abstract:
A distinct energy transfer between the deazaflavin and the flavin is observed in compounds that mimic the DNA repair function of DNA-photolase enzymes (see sketch). Studies on these models prove that the deazaflavin acts solely as photoantenna and suggest that the two cofactors have to be separated within the enzyme to suppress a competitive intercofactor electron transfer reaction.
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