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Acylzirconocene Chloride as an "Unmasked" Acyl Anion
Susumu Harada1, Takeo Taguchi1, Nobuhito Tabuchi1
1School of Pharmacy" Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan), Fax: (+81) 426-76-3257.
Angewandte Chemie (International Ed. in English)
|May 2, 2018
Abstract:
Under mild conditions the acyl group of acylzirconocene chloride 1 formed from an alkene or alkyne and [(C5 H5 )2 ZrHCl] reacts as an "unmasked" acyl anion. The Lewis acid mediated reactions with aldehydes that yield α-ketol products in high yields demonstrate the versatility of this reagent for C-C coupling.