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Updated: Feb 11, 2026

A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates
Published on: May 9, 2014
Functional Molecular Thin Films: Topological Templates for the Chemoselective Ligation of Antigenic Peptides to
Lukas Scheibler1, Pascal Dumy1, Mila Boncheva2
1Institute of Organic Chemistry, University of Lausanne (Switzerland).
Abstract:
The combination of self-assembly and regioselective surface chemistry has made it possible to immobilize peptide recognition sites 1 on a template attached to a gold surface. Each of the seven individual reaction steps, including the final functional biomolecular recognition, was controlled in situ with surface-sensitive detection techniques. The presented strategy is of general importance for the formation of complex supramolecular structures with biologically interesting functionalities at the interfaces.
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