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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Carbohydrate-Carbohydrate Recognition between LewisX Glycoconjugates
Armin Geyer1, Christian Gege1, Richard R Schmidt1
1Fakultät für Chemie M716 der Universität, D-78457 Konstanz (Germany), Fax: (+49) 7531-88-3898.
Abstract:
The strong dependence of the NOE on the molecular mobility rendered the weak bond of a homotypical carbohydrate-carbohydrate recognition detectable in a simplified model system. The membrane-bound LeX trisaccharide 1, which functions as a receptor, transiently binds the dissolved LeX trisaccharide 2, thus slowing down its rotational diffusion. This kind of molecular recognition plays an important part in cell adhesion.
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