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Nucleotide Platination Induced by Visible Light.

Nicole A Kratochwil1, John A Parkinson1, Patrick J Bednarski2

  • 1Department of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ (UK), Fax: (+44) 131-650-6452.

Angewandte Chemie (International Ed. in English)
|May 2, 2018
PubMed
Summary
This summary is machine-generated.

Platinum(IV) complexes undergo a two-step photoreaction with guanosine 5'-monophosphate (5'-GMP) upon visible light irradiation. This process yields a bis-GMP adduct of the platinum(II) complex [Pt(en)]2+.

Keywords:
Bioinorganic chemistryNMR spectroscopyNucleotidesPhotochemistryPlatinum

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Area of Science:

  • Photochemistry
  • Inorganic Chemistry
  • Coordination Chemistry

Background:

  • Platinum complexes are investigated for their therapeutic potential.
  • Understanding the photoreactivity of platinum complexes is crucial for developing new applications.
  • Guanosine 5 ext extapos-monophosphate (5 ext extapos-GMP) is a key biological nucleotide.

Purpose of the Study:

  • To investigate the photoreaction of the Pt(IV) complex trans,cis-[Pt(OCOCH3 )2 I2 (en)] with 5 ext extapos-GMP.
  • To elucidate the mechanism of the two-step photoreaction induced by visible light.
  • To compare the reactivity with a related Pt(IV) dihydroxodiiodo complex.

Main Methods:

  • Irradiation of the Pt(IV) complex in the presence of 5 ext extapos-GMP with visible light.
  • Analysis of the reaction products to identify the final adduct.
  • Spectroscopic characterization of the intermediates and products.

Main Results:

  • A two-step photoreaction was observed, involving photoinduced ligand exchange followed by photoreduction.
  • The bis-GMP adduct of [Pt(en)]2+ was successfully synthesized.
  • The related dihydroxodiiodo complex underwent photoinduced ligand exchange but did not react with 5 ext extapos-GMP.

Conclusions:

  • The Pt(IV) complex trans,cis-[Pt(OCOCH3 )2 I2 (en)] can be photoreduced to a Pt(II) species in the presence of 5 ext extapos-GMP.
  • Visible light irradiation provides a pathway for the synthesis of platinum-nucleotide adducts.
  • The specific ligands on the Pt(IV) complex influence its photoreactivity with nucleotides.