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Updated: Feb 11, 2026

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
Published on: November 27, 2013
2-Nitrobenzylarsonium Compounds That Photorelease Heavy-Atom Cholinergic Ligands for Time-Resolved Crystallographic
Ling Peng1, Florian Nachon1, Jakob Wirz2
1Laboratoire de Chimie Bio-organique, UMR 7514 CNRS - Faculté de Pharmacie, Université Louis Pasteur de Strasbourg, BP 24, F-67401 Illkirch cedex (France), Fax: (+33) 3-88-67-88-91.
Abstract:
As heavy-atom analogues of caged cholinergic ligands, the arsonium compounds 1-3 were synthesized for potential time-resolved crystallographic studies on cholinesterases. Compounds 1 and 3 possess the desired properties for dynamic studies on the catalytic mechanism of cholinesterases: structural similarity with the N-homologue, strong X-ray diffracting effect of arsenic, inhibitory effects on cholinesterases, and excellent photofragmentation kinetics.
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