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Updated: Feb 11, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Conformationally Flexible Biphenyl-phosphane Ligands for Ru-Catalyzed Enantioselective Hydrogenation
Koichi Mikami1, Toshinobu Korenaga1, Masahiro Terada1
1Department of Chemical Technology, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo 152-8552 (Japan), Fax: (+81) 3-5734-2776.
Abstract:
Stereomutation of a BIPHEP/RuCl2 /diamine complex (shown schematically) is possible because of the conformational flexibilty of BIPHEP ligands. The result is an asymmetric activation in the Ru-catalyzed hydrogenation of carbonyl compounds to optically active alcohols. Whereas a racemic BINAP/RuCl2 complex with a chiral diamine activator gives a 1:1 mixture of two diastereomers, unequal amounts of the diastereomers can be produced from a BIPHEP/RuCl2 complex and a chiral diamine. Ar=3,5-dimethylphenyl, BINAP=2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl, BIPHEP=2,2'-bis(diarylphosphanyl)biphenyl.
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