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Updated: Feb 11, 2026

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
Published on: October 2, 2017
The Structural Characterization of Amavadin
Robert E Berry1, Elaine M Armstrong1, Roy L Beddoes1
1Department of Chemistry, University of Manchester, Manchester, M13 9PL (UK), Fax: (+44) 161-275-4616.
Abstract:
Fly agaric accumulate vanadium in the form of amavadin, whose structure has been elucidated (see picture for the crystal structure). Amavadin contains one VIV center coordinated to two (S,S)-hidpa3- ligands (H3 hidpa=2,2'-(hydroxyimino)dipropionic acid) through one η2 -NO- group and two unidentate carboxylato groups from each ligand. The arrangement of the two η2 -NO- groups leads to a chiral vanadium center, which has been characterized in both the Λ and Δ forms. The carboxylato groups of the amavadin anions bind cations, for example, Ca2+ ions, and/or become involved in hydrogen bonding.
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