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Coordination-Ionspray-MS (CIS-MS), a Universal Detection and Characterization Method for Direct Coupling with

Ernst Bayer¹, Petra Gfrörer¹, Claus Rentel¹

¹Forschungsstelle für Nukleinsäure- und Peptidchemie, Universität Tübingen, Auf der Morgenstelle 18, D-72076 Tübingen (Germany), Fax: (+49) 7071-29-5034.

Angewandte Chemie (International Ed. in English)

|May 2, 2018

Summary

This study introduces a new method for Chemical Ionization Mass Spectrometry (CIS-MS) using central atoms to form charged analyte complexes. This technique broadens CIS-MS applicability to diverse polar and nonpolar compounds.

Keywords:

Alkenes Analytical methods Mass spectrometry Olefins

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Area of Science:

Analytical Chemistry
Mass Spectrometry

Background:

Chemical Ionization Mass Spectrometry (CIS-MS) is a powerful analytical technique.
Existing CIS-MS methods have limitations in analyte scope.

Purpose of the Study:

To develop a novel CIS-MS approach for analyzing a wider range of compounds.
To enhance the formation of charged analyte complexes for improved detection.

Main Methods:

On-line addition of central atoms (e.g., Ag^I, B^III, Pd^II, Li^I) to analytes.
Formation of positively or negatively charged analyte complexes.
Coupling with separation techniques.

Main Results:

Successfully formed charged complexes for diverse analytes.
Demonstrated applicability to both polar and nonpolar compounds.
Included examples such as alcohols, olefins, steroids, and fatty acids.

Conclusions:

The developed CIS-MS technique significantly expands the range of detectable compounds.
This method offers a versatile approach for analyzing complex mixtures.
The technique is readily integrated with existing separation methods.