Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Ras Gene02:38

The Ras Gene

7.4K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
7.4K
Switching of BJT01:22

Switching of BJT

873
Switching behavior in Bipolar Junction Transistors (BJTs) is a fundamental aspect utilized in various electronic circuits, particularly for digital logic applications like switches and amplifiers. In a typical switching circuit, a BJT alternates between cut-off and saturation modes, corresponding to the "off" and "on" states, respectively, thus behaving like an ideal switch.
Cut-off Mode ("Off" State): In this state, both the emitter-base and collector-base junctions are...
873
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

5.5K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
5.5K
Molecular Compounds: Formulas and Nomenclature03:10

Molecular Compounds: Formulas and Nomenclature

56.0K
Molecular compounds or covalent compounds result when atoms share electrons to form covalent bonds. Since there is no electron transfer, molecular compounds do not contain ions; instead, they consist of discrete, neutral molecules. 
56.0K
Molecular Models02:00

Molecular Models

43.8K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.8K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.6K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery.

Current opinion in chemical biology·2020
Same author

[Pierre Chardin, a pioneer in the discovery of the genes and proteins of the Ras superfamily].

Medecine sciences : M/S·2020
Same author

Phenotyping Reveals Targets of a Pseudo-Natural-Product Autophagy Inhibitor.

Angewandte Chemie (International ed. in English)·2020
Same author

Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments.

Journal of the American Chemical Society·2020
Same author

Principle and design of pseudo-natural products.

Nature chemistry·2020
Same author

Structure of the human BBSome core complex.

eLife·2020
Same journal

Incorporation of Engineered Cu<sup>0</sup>/Cu<sup>+</sup> Interfaces in Metal-Organic Frameworks for Boosting CO<sub>2</sub> Hydrogenation to Methanol.

Angewandte Chemie (International ed. in English)·2026
Same journal

Planar Chiral Carbazole-Naphthalene Bisimide Hetero-Cyclophane for Circularly Polarized Delayed Fluorescence.

Angewandte Chemie (International ed. in English)·2026
Same journal

Charge-Transfer Exciton Flows: Red Luminescent Zn<sub>8</sub>D<sub>14</sub>A<sub>4</sub> Nanotubes.

Angewandte Chemie (International ed. in English)·2026
Same journal

Au(III) Complexes as Pyroptosis Inducers by Targeting Mitochondrial DNA for Tumor Immunity.

Angewandte Chemie (International ed. in English)·2026
Same journal

Suppressing Interfacial-Accelerated Degradation in Perovskite Solar Cells via Supramolecular Co-Assembly.

Angewandte Chemie (International ed. in English)·2026
Same journal

Isolation and Reactivity of a Stannabismuthene.

Angewandte Chemie (International ed. in English)·2026
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
09:14

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth

Published on: August 11, 2011

16.3K

Ras-A Molecular Switch Involved in Tumor Formation.

Alfred Wittinghofer1, Herbert Waldmann1

  • 1Max-Planck-Institut für molekulare Physiologie Otto-Hahn-Strasse 11, 44227 Dortmund, Germany, Fax: (+49) 231-1332199.

Angewandte Chemie (International Ed. in English)
|May 2, 2018
PubMed
Summary
This summary is machine-generated.

Ras proteins act as molecular switches controlling cell growth. Mutations in Ras disrupt this function, leading to cancer. Understanding Ras is key to developing targeted cancer therapies.

Keywords:
GTP hydrolysisantitumor agentsdrug researchenzyme inhibitorsproteins

More Related Videos

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans
08:12

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

Published on: October 5, 2020

3.4K
Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

985

Related Experiment Videos

Last Updated: Feb 11, 2026

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
09:14

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth

Published on: August 11, 2011

16.3K
Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans
08:12

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

Published on: October 5, 2020

3.4K
Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

985

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Ras proteins are key regulators of cellular signaling pathways.
  • Mutations in Ras are implicated in approximately 20-30% of human cancers.
  • Ras functions as a molecular switch, cycling between GDP-bound (OFF) and GTP-bound (ON) states.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying Ras protein function.
  • To understand how mutations in Ras lead to oncogenesis.
  • To identify potential targets for Ras-directed anticancer drug development.

Main Methods:

  • The study focuses on the biochemical properties of Ras proteins, including their GTP-hydrolyzing activity.
  • Investigates the role of GTPase-activating protein (GAP) in regulating Ras activity.
  • Examines the impact of specific point mutations on Ras function and its role in signal transduction.

Main Results:

  • Ras proteins bind GDP/GTP with high affinity and exhibit GTP-hydrolyzing activity in the presence of GAP.
  • Oncogenic Ras mutations impair GTPase activity, locking the protein in an active state.
  • This sustained activation of Ras contributes to uncontrolled cell growth and tumor formation.

Conclusions:

  • Ras proteins are critical regulators of cell signaling, acting as molecular switches.
  • Dysfunctional Ras signaling due to mutations is a significant driver of human cancer.
  • Further research into Ras molecular mechanisms is crucial for developing effective antitumor strategies.