Highly Sensitive Novel Biosensor Based on an Immobilized lac Repressor
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Updated: Feb 11, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
Ibolya Bontidean1, Ashok Kumar1, Elisabeth Csöregi1
1Department of Biotechnology Center for Chemistry and Chemical Engineering Lund University 22100, Lund (Sweden) Fax: (+46) 46-222-4713.
Abstract:
Sensitive repressors: The conformational change that occurs in the lac repressor protein when it binds to an inducer molecule has been used to develop a biosensor that permits the detection of the corresponding operator sequence or specific inducer molecules. A capacitive signal transducer was used to translate the conformational change of the lac repressor protein, covalently immobilized on a gold electrode (see schematic representation, A=bound inducer molecule or DNA), into a measurable signal.
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