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Synthetic seco Forms of (-)-Diazonamide A
Jing Li1, Xin Chen1, Anthony W G Burgett1
1Department of Biochemistry University of Texas, Southwestern Medical Center at Dallas Dallas, TX 75390-9038 (USA) Fax: (+1) 214-648-6455.
Abstract:
One bond and a water molecule separate title compound 1 from the potently bioactive peptide metabolite diazonamide A. Compositionally similar, yet topographically distinct, diazonamide A and 1 are both toxic towards cultured human cancer cells although the mechanisms underlying their actions likely differ. The quest towards completely synthetic diazonamides continues.
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