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An Atom-Economic Three-Carbon Chain Extension to Give Enamides
Barry M Trost1, Jean-Philippe Surivet1
1Department of Chemistry Stanford University Stanford, CA 94305-5080 (USA) Fax: (+1) 650-725-0002.
Abstract:
Di- or trisubstituted alkenes of defined geometry, with terminal enamide groups, are formed in an atom-economic three-carbon chain extension of alkynes with allyl amides catalyzed by ruthenium (see, for example, Equation (1); Boc=tert-butoxycarbonyl, TMS=trimethylsilyl).
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