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Updated: Feb 11, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
Identification and Isolation of a Receptor for N-Methyl Alkylammonium Salts: Molecular Amplification in a
Graham R L Cousins1, Ricardo L E Furlan1, Yiu-Fai Ng1
1Cambridge Centre for Molecular Recognition University Chemical Laboratory, University of Cambridge Lensfield Road, Cambridge, CB2 1EW (UK) Fax: (+44) 1223-336-017.
Abstract:
A cyclic pseudo-peptide receptor for acetylcholine has been amplified and isolated from a dynamic combinatorial library by virtue of templated stabilization under thermodynamic control (see scheme, TFA=trifluoroacetic acid). This is a demonstration of significant molecular amplification in dynamic systems to evolve a novel receptor.
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