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Updated: Feb 11, 2026

Microwave-driven Synthesis of Iron Oxide Nanoparticles for Fast Detection of Atherosclerosis
Published on: March 22, 2016
Synthesis of Nanophase Iron Oxide in Lumazine Synthase Capsids
Wayne Shenton1, Stephen Mann1, Helmut Cölfen2
1School of Chemistry University of Bristol Bristol BS8 1TS (UK) Fax: (+44) 117-929-0509.
Abstract:
An enzyme-based bio-nanoreactor: By acting as a mineralization template, lumazine synthase, a 60-subunit enzyme complex which has a hollow porous shell, can fabricate nanocrystalline iron oxide. Fe ions can permeate the capsid through hydrophilic funnel-shaped channels lined with glutamic acid residues and become encapsulated in the cavity as FeIII oxide. The capsid increases in size from 15 to 30 nm in diameter through formation of a higher order structure as the concentration of FeIII increases.
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