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Related Experiment Video

Updated: Feb 11, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Diversion colitis and pouchitis: A mini-review.

Kentaro Tominaga1, Kenya Kamimura2, Kazuya Takahashi1

  • 1Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan.

World Journal of Gastroenterology
|May 2, 2018
PubMed
Summary

Diversion colitis and pouchitis are inflammatory conditions affecting surgically diverted bowels. This review summarizes recent treatments for these conditions, aiding physicians in managing patients with diversion disease.

Keywords:
Diversion colitisDiversion pouchitisIleitisInflammatory bowel disease

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Area of Science:

  • Gastroenterology
  • Surgical Pathology

Background:

  • Diversion colitis and pouchitis are inflammatory conditions affecting surgically diverted gastrointestinal segments.
  • These conditions result from fecal stream exclusion and nutrient deprivation for luminal bacteria.

Purpose of the Study:

  • To review and summarize recently reported treatments for diversion disease.
  • To assist physicians in managing patients with diversion colitis and pouchitis.

Main Methods:

  • Literature review of recently reported treatments for diversion disease.

Main Results:

  • Surgical stoma closure is curative for diversion disease.
  • Pharmacologic treatments like short-chain fatty acids, mesalamine, and corticosteroids show efficacy in non-surgical candidates.
  • No established criteria exist for assessing diversion colitis severity or guiding management.

Conclusions:

  • Current management of diversion disease relies on surgical intervention or pharmacologic treatments.
  • Further research is needed to establish assessment criteria and standardized management strategies for diversion colitis and pouchitis.