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Pharmacogenetics of Chemotherapy-Induced Cardiotoxicity

Vivian Y Chang1,2, Jessica J Wang3

  • 1Department of Pediatrics, Division of Hematology/Oncology, University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA.

Current Oncology Reports
|May 2, 2018
PubMed
Abstract

Insights

Pharmacogenetics and pharmacogenomics help understand chemotherapy-induced cardiotoxicity. Genetic testing is recommended for children receiving specific chemotherapy, but more research is needed for adults.

Area of Science:

  • Pharmacology
  • Genetics
  • Oncology

Background:

  • Chemotherapy-induced cardiotoxicity is a significant concern for cancer patients.
  • Understanding genetic predispositions can personalize treatment and mitigate risks.

Purpose of the Study:

  • To review current knowledge on pharmacogenetics and pharmacogenomics in chemotherapy-induced cardiotoxicity.
  • To highlight the role of genetic variations in susceptibility to cardiotoxic effects of chemotherapy.

Main Methods:

  • Review of existing literature, including in vitro cytotoxic assays, candidate gene studies, and genome-wide association studies.
  • Analysis of current recommendations for pharmacogenomic testing in specific patient populations.

Main Results:

  • Genetic variations influence susceptibility to chemotherapy-induced cardiotoxicity.
  • Pharmacogenomic testing is recommended for pediatric patients receiving doxorubicin or daunorubicin therapy, targeting specific gene variants (RARG rs2229774, SLC28A3 rs7853758, UGT1A6*4 rs17863783).
  • No specific testing recommendations currently exist for adult patients.

Conclusions:

  • Pharmacogenetics and pharmacogenomics play a clear role in cardiotoxicity susceptibility.
  • Larger studies are essential to identify more susceptibility markers and develop risk profiling for improved outcomes in cancer survivors.
Keywords:
Chemotherapy-induced cardiomyopathyChemotherapy-induced cardiotoxicityPharmacogenetics of cancerPharmacogenomics of cancer

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