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Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial

Graciela Freitas Zarbato1, Mariana Pereira de Souza Goldim1, Amanda Della Giustina1

  • 1Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubarao, SC, Brazil.

Neurotoxicity Research
|May 2, 2018
PubMed

Insights

Dimethyl fumarate (DMF) effectively reduced neuroinflammation, oxidative stress, and cognitive impairment in rats with sepsis. This study highlights DMF

Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Sepsis triggers a host response leading to central nervous system (CNS) dysfunction and long-term cognitive deficits.
  • Dimethyl fumarate (DMF) demonstrates anti-inflammatory and antioxidant properties relevant to CNS disorders.

Purpose of the Study:

  • To investigate the therapeutic effects of Dimethyl fumarate (DMF) on acute and chronic brain dysfunction in a rat model of experimental sepsis.

Main Methods:

  • Male Wistar rats underwent cecal ligation and puncture (CLP) to induce sepsis.
  • Animals received Dimethyl fumarate (DMF) or n-acetylcysteine (NAC) as treatment.
  • Evaluations included neuroinflammation markers, oxidative stress, antioxidant enzyme activity, and cognitive function tests.

Main Results:

  • Sepsis induced increased neuroinflammation, oxidative stress, and cognitive impairment in rats.
  • Dimethyl fumarate (DMF) treatment significantly reversed these sepsis-induced changes in brain structures.
  • DMF administration attenuated cytokine levels, myeloperoxidase activity, and oxidative damage while restoring antioxidant enzyme activity.

Conclusions:

  • Dimethyl fumarate (DMF) effectively mitigates sepsis-induced neuroinflammation and oxidative stress.
  • DMF treatment ameliorates both acute and long-term cognitive impairments following experimental sepsis.
  • These findings suggest DMF as a potential therapeutic agent for sepsis-associated brain dysfunction.
Keywords:
Cognitive impairmentDimethyl fumarateNeuroinflammationOxidative stressSepsis

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