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Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk
Chenyang Li1, Weijun Peng1,2, Heng Zhang1,3
1a Department of Epidemiology and Biostatistics, School of Public Health , Tongji Medical College of Huazhong University of Science & Technology , Wuhan , China.
Objectives:
To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women.
Methods:
A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. A logistic regression approach was applied to estimate the relationship between the polymorphisms and haplotypes of AT2Rgene with PIH risk.
Results:
No relationship between AT2R gene polymorphisms and PIH was detected. The haplotype analysis also showed a negative result.
Conclusions:
rs5193, rs1403543 and rs12710567 of AT2R gene might have no effect on PIH risk among Chinese Han women.
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Internal Receptors
Relative Risk
Organization of Genes

