Related Experiment Video

Updated: Feb 11, 2026

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
08:55

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

9.9K

A Comparative Safety Profile Assessment of Oncolytic Virus Therapy Based on Clinical Trials

Takuma Matsuda1, Hiroyo Karube1, Atsushi Aruga1

  • 1Cooperative Major in Advanced Biomedical Sciences, Joint Graduate School of Tokyo Women's Medical University and Waseda University, Tokyo.

Therapeutic Innovation & Regulatory Science
|May 2, 2018
PubMed

Insights

Oncolytic virus therapy (OVT) shows a manageable safety profile in clinical trials, with most adverse events being infection-related symptoms. Further trials are encouraged to solidify OVT as a safe cancer treatment.

Area of Science:

  • Oncology
  • Virology
  • Immunotherapy

Background:

  • Oncolytic virus therapy (OVT) is an emerging cancer treatment modality.
  • Genetically modified viruses are developed as oncolytic agents.
  • The first OVT gained FDA approval in 2015, signaling growing clinical interest.

Purpose of the Study:

  • To conduct a risk assessment of OVT based on existing clinical trial safety data.
  • To evaluate the safety and toxicity profiles of OVTs.
  • To encourage further clinical development of OVTs.

Main Methods:

  • Systematic review of safety data from all available clinical trials of OVTs.
  • Analysis of adverse events (AEs) reported in a publicly accessible database.
  • Assessment of AE frequency, severity, and manageability.

Main Results:

  • The most frequent AEs associated with OVT were infection-related symptoms like fatigue, chills, fever, and nausea.
  • Few serious adverse events were observed across different viruses and gene modifications.
  • Systemic OVT infusion led to a high incidence of AEs, but most were manageable with standard medications.

Conclusions:

  • OVTs exhibit a generally favorable safety profile with manageable adverse events.
  • Further clinical trials are necessary to address challenges and confirm the safety of OVTs for cancer treatment.
Keywords:
clinical trialoncolytic virus therapyregulatory sciencerisk assessmentsafety

More Related Videos

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.3K
Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy08:51

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

9.5K

Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.9K
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.6K
Survey Safety01:28

Survey Safety

Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
413
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
267