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Nanoparticle-Enhanced Plasmonic Biosensor for Digital Biomarker Detection in a Microarray.

Alexander Belushkin1, Filiz Yesilkoy1, Hatice Altug1

  • 1Institute of BioEngineering , École Polytechnique Fédérale de Lausanne , CH-1015 Lausanne , Switzerland.

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Summary
This summary is machine-generated.

This study introduces a novel plasmonic biosensor for detecting single molecules. The device visualizes gold nanoparticles (NPs) for sensitive biomarker detection in diagnostics.

Keywords:
biosensorsdigital molecule detectiongold nanoparticlesplasmonic imagingplasmonic nanohole arrayssepsis biomarker detection

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Area of Science:

  • Nanoplasmonics
  • Biosensing
  • Biomolecular Detection

Background:

  • Nanoplasmonic devices leverage light-matter interactions for diverse applications.
  • Accurate detection of biomarkers is crucial for medical diagnostics and research.
  • Existing methods may lack sensitivity or require complex instrumentation.

Purpose of the Study:

  • To develop a bright-field imaging plasmonic biosensor for visualizing single nanoparticles.
  • To enable sensitive detection of NP-labeled molecules using gold nanohole arrays (Au-NHAs).
  • To demonstrate the sensor's efficacy in detecting clinically relevant biomarkers.

Main Methods:

  • Utilized large-area gold nanohole arrays (Au-NHAs) as the sensor platform.
  • Employed bright-field imaging to visualize single subwavelength gold nanoparticles (NPs).
  • Implemented a sandwich immunoassay for detecting biotinylated bovine serum albumin (bBSA) and C-reactive protein (CRP).

Main Results:

  • Generated image heatmaps revealing single NP locations as high-contrast spikes.
  • Achieved detection limits of 10 pg/mL for bBSA and 27 pg/mL for CRP within 2 hours.
  • Demonstrated sensitivity significantly lower (4 orders of magnitude) than clinically relevant concentrations.

Conclusions:

  • The developed plasmonic biosensor enables sensitive and rapid detection of individual NP-labeled molecules.
  • The sensor platform is robust, scalable, and fabricated using low-cost manufacturing.
  • This technology offers a powerful platform for multiplexed biomarker detection in various settings.