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Reduced anaerobic glycolysis in oral contraceptive users
R Vijayalakshmi1, M S Bamji, B A Ramalakshmi
1National Institute of Nutrition, Indian Council of Medical Research, Hyderabad.
Contraception
|July 1, 1988
Abstract:
Oral contraceptives containing combinations of estrogens and progestogens are known to impair glucose tolerance. The biochemical mechanisms underlying this lesion are speculative. In the present study women treated with OC for periods exceeding 10 cycles showed significant reduction in the activity of the key glycolytic enzyme phosphofructokinase (40%) and the levels of lactate (42%) in the erythrocytes compared to controls. These observations in women are analogous to those made earlier in female rats.
Keywords:
AsiaBiologyBlood ProteinsCarbohydrate Metabolic EffectsContraceptionContraceptive AgentsContraceptive Agents, EstrogenContraceptive Agents, FemaleContraceptive Agents, ProgestinContraceptive Methods--side effectsDeveloping CountriesEnzyme InhibitorsEnzymesEnzymes And Enzyme InhibitorsEthinyl EstradiolExaminations And DiagnosesFamily PlanningGlucose Metabolism EffectsGlucose Tolerance TestHemic SystemIndiaLaboratory Examinations And DiagnosesLaboratory ProceduresMetabolic EffectsNorgestrelOral Contraceptives, Combined--side effectsOral Contraceptives--side effectsPhysiologyProgesteroneSouthern Asia