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Correlation Between Ktrans and Microvessel Density in Different Tumors: A Meta-analysis
Hans Jonas Meyer1, Andreas Wienke2, Alexey Surov3
1Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany Hans-Jonas.Meyer@medizin.uni-leipzig.de.
Anticancer Research
|May 2, 2018
Summary
This meta-analysis examined the relationship between Ktrans and microvessel density in various tumors. Correlations varied significantly across tumor types, with glioma showing a strong positive association.
Area of Science:
- Radiology and Oncology
- Medical Imaging Analysis
Background:
- Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) assesses tumor angiogenesis.
- DCE MRI parameters like Ktrans can indicate tumor behavior.
- Microvessel density (MVD) is a key indicator of tumor angiogenesis.
Purpose of the Study:
- To conduct a meta-analysis on the association between Ktrans and MVD in different tumor types.
- To synthesize existing research data on Ktrans-MVD relationships.
Main Methods:
- Screened MEDLINE for studies reporting Ktrans and MVD associations up to July 2017.
- Included 16 studies in the meta-analysis.
- Extracted data including tumor type, patient numbers, and correlation coefficients.
Main Results:
- The pooled correlation coefficient between Ktrans and MVD was 0.23 (95%CI=0.07-0.38).
- Individual tumor analyses revealed varying correlations: rectal cancer (ρ=-0.07), prostate cancer (ρ=0.08), and glioma (ρ=0.70).
- Correlation coefficients ranged from -0.65 to 0.75 across all studies.
Conclusions:
- The association between Ktrans and MVD differs across various tumor types.
- Gliomas exhibit a strong positive correlation between Ktrans and MVD.
- Further research may clarify these tumor-specific relationships.
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