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Published on: August 21, 2019
Prognostic Impact of Postoperative C-reactive Protein for Non-small Cell Lung Cancer Following Lobectomy
Shuichi Shinohara1, Masakazu Sugaya2, Takamitsu Onitsuka2
1Department of Thoracic Surgery, Chubu Rosai Hospital, Nagoya, Japan musictiger617@gmail.com.
Background/Aim:
C-reactive protein (CRP) is associated with cancer progression; however, the prognostic impact of postoperative CRP remains controversial. The aim of this study was to investigate the prognostic significance of postoperative CRP in patients with resected non-small cell lung cancer (NSCLC).
Patients And Methods:
A total of 198 consecutive patients with NSCLC that had undergone lobectomy were retrospectively reviewed. CRP was measured on postoperative days 1, 3, and 5. Patients were divided into two groups according to the median of CRP on postoperative day 3 (CRP3); the high and low CRP3 groups (n=99, respectively).
Results:
Five-year overall survival was significantly higher in the high CRP3 group than the low CRP3 (75.3% vs. 86.5%; p=0.016), as was the 5-year recurrence-free survival (62.7% vs. 73.0%; p=0.016). Multivariate analysis revealed that high CRP3 was associated with a favorable prognosis (hazard ratio(HR)=0.36; p<0.001).
Conclusion:
High CRP3 may be a favorable prognostic predictor in patients with NSCLC following lobectomy.
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