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Updated: Feb 11, 2026

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome
Published on: March 31, 2023
Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe
Santosh Lamichhane1, Partho Sen1, Alex M Dickens1
1Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland.
Abstract:
It is well established that gut microbes and their metabolic products regulate host metabolism. The interactions between the host and its gut microbiota are highly dynamic and complex. In this review we present and discuss the metabolomic strategies to study the gut microbial ecosystem. We highlight the metabolic profiling approaches to study faecal samples aimed at deciphering the metabolic product derived from gut microbiota. We also discuss how metabolomics data can be integrated with metagenomics data derived from gut microbiota and how such approaches may lead to better understanding of the microbial functions. Finally, the emerging approaches of genome-scale metabolic modelling to study microbial co-metabolism and host-microbe interactions are highlighted.
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