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Prognostic factors and the management of anaplastic meningioma

Gui-Jun Zhang1, Yun-Sheng Zhang2, Guo-Bin Zhang1

  • 1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Tiantan Xili 6, Dongcheng District, Beijing, 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Brain Tumor, Beijing, China.

Clinical Neurology and Neurosurgery
|May 2, 2018
PubMed
Abstract

Insights

Anaplastic meningioma patients benefit from gross-total resection and postoperative radiotherapy. These treatments significantly improve progression-free survival and overall survival, offering better outcomes for this aggressive tumor type.

Area of Science:

  • Neurosurgery
  • Oncology
  • Pathology

Background:

  • Anaplastic meningiomas (AMs) are aggressive tumors with high recurrence and metastasis rates.
  • Limited studies exist on the prognosis and management of AM patients.
  • This study aims to enhance understanding of AM prognosis, management, and clinical history.

Purpose of the Study:

  • To analyze prognostic factors for anaplastic meningiomas.
  • To evaluate the effectiveness of different management strategies for AM.
  • To improve the understanding of AM patient outcomes.

Main Methods:

  • Retrospective analysis of 56 patients diagnosed with AM between December 2008 and January 2016.
  • Categorization into primary and secondary AM groups.
  • Statistical analysis of prognostic factors and treatment outcomes, including progression-free survival (PFS) and overall survival (OS).

Main Results:

  • The 1-, 3-, and 5-year PFS rates were 78.6%, 41.1%, and 29.7%, respectively; OS rates were 82.1%, 50.1%, and 45.0%, respectively.
  • Gross-total resection (GTR) was a significant favorable factor for both PFS and OS.
  • Postoperative radiotherapy (PRT) was significantly associated with longer PFS and OS.

Conclusions:

  • Gross-total resection (GTR) is a critical and favorable treatment strategy for anaplastic meningioma patients.
  • Postoperative radiotherapy (PRT) following surgical resection is essential for improving patient outcomes.
  • These findings highlight the importance of aggressive surgical and adjuvant treatment for AM.
Keywords:
Anaplastic meningiomaPrognosisTreatmentTumor progression

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