Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Sensory Functions of the Skin

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...

Network Function of a Circuit

Network Function of a Circuit

Frequency response analysis in electrical circuits provides vital insights into a circuit's behavior as the frequency of the input signal changes. The transfer function, a mathematical tool, is instrumental in understanding this behavior. It defines the relationship between phasor output and input and comes in four types: voltage gain, current gain, transfer impedance, and transfer admittance. The critical components of the transfer function are the poles and zeros.

What is a Sensory System?

What is a Sensory System?

Sensory systems detect stimuli—such as light and sound waves—and transduce them into neural signals that can be interpreted by the nervous system. In addition to external stimuli detected by the senses, some sensory systems detect internal stimuli—such as the proprioceptors in muscles and tendons that send feedback about limb position.

Fruit Development, Structure, and Function

Fruit Development, Structure, and Function

Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.

Second-Order Circuits

Second-Order Circuits

Integrating two fundamental energy storage elements in electrical circuits results in second-order circuits, encompassing RLC circuits and circuits with dual capacitors or inductors (RC and RL circuits). Second-order circuits are identified by second-order differential equations that link input and output signals.
Input signals typically originate from voltage or current sources, with the output often representing voltage across the capacitor and/or current through the inductor. For example, in...

Sensory Modalities

Sensory Modalities

Sensation typically is the process by which the sensory receptors and sense organs detect stimuli from the internal and external environment and transmit this information to the central nervous system for processing.
General senses refer to the broad category of sensory information detected by receptors in the body and can be further grouped into somatic and visceral senses. Somatic sensations include touch, pressure, temperature, and pain and are essential for navigating our environment and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Experience Dependence of Alpha Rhythms and Neural Dynamics in the Mouse Visual Cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024

Same author

cFOS as a biomarker of activity maturation in the hippocampal formation.

Frontiers in neuroscience·2023

Same author

Synaptic and circuit mechanisms prevent detrimentally precise correlation in the developing mammalian visual system.

eLife·2023

Same author

A new role for visual experience in top-down cortical development.

Neuron·2021

Same author

Polynomial, piecewise-Linear, Step (PLS): A Simple, Scalable, and Efficient Framework for Modeling Neurons.

Frontiers in neuroinformatics·2021

Same author

Input-Independent Homeostasis of Developing Thalamocortical Activity.

eNeuro·2021

Search research articles

Related Experiment Video

Updated: Feb 11, 2026

Visualization of Thalamocortical Axon Branching and Synapse Formation in Organotypic Cocultures

Visualization of Thalamocortical Axon Branching and Synapse Formation in Organotypic Cocultures

Published on: March 28, 2018

Thalamocortical function in developing sensory circuits.

Matthew T Colonnese¹, Marnie A Phillips¹

¹Department of Pharmacology and Physiology, Institute for Neuroscience, The George Washington University, United States.

Current Opinion in Neurobiology

|May 2, 2018

Summary

This summary is machine-generated.

Brain circuits shift from burst transmission to high-resolution sensory processing before sensory experiences begin. This transition involves remodeling inhibitory circuits in the thalamus and cortex for better stimulus discrimination.

More Related Videos

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Published on: February 24, 2023

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Related Experiment Videos

Last Updated: Feb 11, 2026

Visualization of Thalamocortical Axon Branching and Synapse Formation in Organotypic Cocultures

Visualization of Thalamocortical Axon Branching and Synapse Formation in Organotypic Cocultures

Published on: March 28, 2018

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Published on: February 24, 2023

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Area of Science:

Neuroscience
Developmental Neuroscience
Systems Neuroscience

Background:

Thalamocortical activity patterns change significantly before sensory experiences like birth or eye-opening.
Early circuit function prioritizes burst transmission for sensory organ input, sacrificing stimulus discrimination.
This early tuning relies on corticothalamic excitatory feedback and subplate neurons.

Purpose of the Study:

To explain the shift in thalamocortical circuit function from pre-sensory to sensory processing.
To elucidate the mechanisms underlying the transition to high-resolution sensory processing.
To highlight the role of inhibitory circuit remodeling in this developmental switch.

Main Methods:

Analysis of spontaneous and evoked thalamocortical activity patterns.
Investigation of circuit dynamics during the transition to sensory experience.
Focus on the remodeling of inhibitory circuits in the thalamus and cortex.

Main Results:

Thalamocortical circuits switch from burst transmission to active sensory processing.
This switch is crucial for enabling high-resolution sensory discrimination.
Coordinated remodeling of inhibitory circuits in the thalamus and cortex underlies this functional transition.

Conclusions:

Understanding early circuit development is vital for addressing developmental dysfunctions.
The shift to sensory circuits involves precise inhibitory circuit remodeling.
Distinct rules govern pre-sensory and sensory circuit function, impacting translational research.