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Non-invasive estimation of cardiac index in healthy volunteers

C T Eyeington, P Ancona, L Cioccari

  • 1Research Fellow, Department of Anaesthesia, Austin Hospital; Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventative Medicine, Monash University; Melbourne, Victoria.

Anaesthesia and Intensive Care
|May 3, 2018
PubMed

Insights

Healthy adults experience a decline in cardiac index (CI) and stroke volume index (SVI) with age. This non-invasive study reveals age-related hemodynamic changes in healthy individuals.

Area of Science:

  • Cardiovascular Physiology
  • Geriatric Medicine
  • Medical Devices

Background:

  • Understanding age-related changes in cardiovascular hemodynamics is crucial for accurate clinical interpretation.
  • Non-invasive monitoring methods are advancing the assessment of hemodynamic parameters.

Purpose of the Study:

  • To non-invasively measure cardiac index (CI) and related hemodynamic parameters in healthy volunteers.
  • To investigate the relationship between age and hemodynamic parameters in a healthy adult population.

Main Methods:

  • Prospective, observational study involving 97 healthy volunteers aged 20-59 years.
  • Utilized the ClearSight™ device for non-invasive hemodynamic measurements.
  • Recorded 514 observations, measuring CI, stroke volume index (SVI), and systemic vascular resistance index.

Main Results:

  • Mean CI was 3.5 l/min/m², mean SVI was 47 ml/m², and mean systemic vascular resistance index was 2,242 dyne.s/cm⁵/m².
  • An inverse linear relationship was found between age and CI (P <0.0001).
  • CI decreased by 0.044 l/min/m² per year, primarily due to a decrease in SVI (0.45 ml/m² per year).

Conclusions:

  • Healthy aging is associated with a decline in cardiac index, mainly driven by reduced stroke volume.
  • These findings are significant for the clinical interpretation of hemodynamic data in individual patients.
  • Non-invasive measurement of hemodynamic parameters provides valuable insights into age-related physiological changes.

Keywords:
cardiac indexcardiac outputhaemodynamic monitoringhealthy volunteersnon-invasivestroke volume

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