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Updated: Feb 11, 2026

Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines
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Published on: September 10, 2014

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FOXO3a Reverses the Cisplatin Resistance in Ovarian Cancer

Mudan Lu1, Xuan Chen2, Jianping Xiao1

  • 1Central laboratory, The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China.

Archives of Medical Research
|May 3, 2018
PubMed
Abstract

Insights

Decreased FOXO3a expression is linked to platinum drug resistance in ovarian cancer. Restoring FOXO3a levels can reverse this resistance, offering a potential therapeutic target for improving ovarian cancer treatment.

Area of Science:

  • Gynecology
  • Oncology
  • Molecular Biology

Background:

  • Ovarian cancer is a significant threat to female reproductive health.
  • Platinum-based chemotherapy is a primary treatment, but drug resistance is a major clinical challenge.
  • Previous research indicated that reduced FOXO3a expression may correlate with poor prognosis in ovarian cancer.

Purpose of the Study:

  • To investigate the role of FOXO3a in the development of platinum drug resistance in ovarian cancer.
  • To determine if FOXO3a expression levels influence the efficacy of platinum-based chemotherapy.

Main Methods:

  • Cell viability was assessed using CCK-8 assays.
  • Apoptosis and cell cycle analysis were performed using FACS.
  • FOXO3a protein expression was quantified via Western blot.

Main Results:

  • FOXO3a expression was significantly upregulated in platinum-treated A2780 cells compared to resistant A2780/DDP cells.
  • Overexpression of FOXO3a in ovarian cancer cells reversed platinum drug resistance.
  • These findings suggest a direct link between FOXO3a levels and platinum sensitivity.

Conclusions:

  • FOXO3a plays a critical role in the mechanism of platinum drug resistance in ovarian cancer.
  • Modulating FOXO3a expression may represent a novel strategy to overcome chemotherapy resistance.
  • Further research into FOXO3a's function could lead to improved ovarian cancer treatment outcomes.
Keywords:
FOXO3aOvarian cancerPlatinum drug resistance

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