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Synthesis and Exfoliation of Discotic Zirconium Phosphates to Obtain Colloidal Liquid Crystals
Published on: May 25, 2016
A short synthesis of Dronedarone
Barbara Piotrkowska1, Sven Nerdinger2, Erwin Schreiner2
1Selvita Services sp. z o.o., Bobrzynskiego 14, Krakow 30-348, Poland.
Abstract:
A modification of the Nenitzescu reaction was used to obtain Dronedarone from quinonimine 20 and 1,3-diketone 14 (R = CH2CH2CH2NBu2) in a two-stage process in almost 55% overall yield. Our results represent significant improvement over other state-of-the-art methods as no extra steps for the decoration of the benzofuran core are required.
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