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Crizotinib-induced simultaneous multiple cardiac toxicities.

Takuya Oyakawa1, Nao Muraoka2, Kei Iida2

  • 1Division of Cardiology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan. t.oyakawa@scchr.jp.

Investigational New Drugs
|May 3, 2018
PubMed
Summary
This summary is machine-generated.

Crizotinib treatment can cause simultaneous cardiac toxicities, including bradycardia, QT prolongation, and pericarditis. Close patient monitoring is essential due to these potential severe cardiovascular events.

Keywords:
Cardiac toxicityCardio-oncologyCrizotinibLung cancerMET

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Area of Science:

  • Oncology
  • Cardiology
  • Pharmacology

Background:

  • Crizotinib, a receptor tyrosine kinase inhibitor targeting ALK, ROS1, and MET, is used in cancer therapy.
  • Known cardiac toxicity associated with crizotinib includes bradycardia and QT prolongation.
  • The potential for simultaneous cardiac adverse events requires further investigation.

Observation:

  • Patients treated with crizotinib presented with a combination of cardiac complications.
  • Observed events included bradycardia, QT prolongation, ventricular rhythm, ventricular fibrillation, and pericarditis concurrently.
  • This simultaneous occurrence highlights a complex cardiotoxic profile.

Findings:

  • Crizotinib can induce multiple cardiac adverse events at the same time.
  • The combination of arrhythmias and pericarditis represents a severe manifestation of cardiotoxicity.
  • These findings underscore the multifaceted nature of crizotinib-induced cardiac damage.

Implications:

  • Intensive cardiac monitoring is crucial for patients receiving crizotinib.
  • Understanding simultaneous cardiotoxicity can guide risk stratification and management strategies.
  • Further research into the mechanisms of combined cardiac events is warranted.